Abstract: Taking the 11 provinces of the Yangtze River Economic Belt as the research object,this paper constructed the index system of scientific and technological innovation and high-quality economic development,and it measured the coupling coordination degree of scientific and technological innovation and high-quality economic development from 2011 to 2020 by the entropy weight method and the coupling coordination model.The results showed that the index and coupling coordination degree of scientific and technological innovation and high-quality economic development in the Yangtze River Economic Belt are on the rise,but there were regional differences.Therefore,it proposed that the radiation effect should be strengthened in the lower reaches of the Yangtze River to reduce regional differences.the midstream to undertake the transfer of manufacturing;The upstream zone would increase investment in R&D and innovation,and develop characteristic economy according to local conditions.